GDNF相关论文
目的:结肠动力紊乱在糖尿病患者中很常见。结肠运动由肠神经元控制,近年来,电针刺激已成为治疗结肠动力障碍性疾病的一种有效的新......
哺乳动物雌性生殖研究领域传统观念认为,哺乳动物如小鼠和人类在出生时或者出生数天内卵巢中卵细胞的数目便确定了,卵巢中卵细胞无......
精原干细胞具有自我复制和分化成精子的能力,是动物体内唯一能进行遗传信息传递的干细胞。因此,精原干细胞既是干细胞生物学的重要......
第一部分:胶质细胞源性神经营养因子(GDNF)及其受体(RET)在腹泻型肠易激综合征患者结肠粘膜中的表达改变及与症状的相关性分析研究背景......
本文探索了血清浓度以及SCF、LIF、GDNF对牛精原干细胞体外存活和增殖的影响,并对其进行了鉴定.试验1:以高糖DMEM为基础培养液,添......
目的:研究羧甲基壳聚糖(Carboxymethylated chitosan,CMCS)对氧化应激诱导大鼠雪旺细胞(Schwann cells,SCs)损伤的保护作用,及脑源......
目的:研究羧甲基壳聚糖(Carboxymethylated chitosan,CMCS)对氧化应激诱导大鼠雪旺细胞(Schwann cells,SCs)损伤的保护作用,及脑源......
Background High-grade(HG)gliomas are the most common primary brain tumors.Their malignancy is promoted by the complex cr......
胶质细胞系源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)基因在胶质瘤细胞中异常高转录与其启动子Ⅱ区甲......
GDNF(glial cell-line derived neurotrophic factor,)是一种分泌性蛋白,可促进胶质瘤细胞增殖 。 GDNF 对胶质瘤细胞的增殖作用须......
Downregulated expression of GFRa1 promotes HCC progression though Epithelial-to-Mesenchymal Transiti
Background and Purposes: Accumulating evidences implies that the neurotrophic factor and their receptors contribute to t......
目的 精神分裂症的病因至今未明,大量证据表明神经营养因子可能参与了精神分裂症的发生。而脑源性神经营养因子(BDNF)和胶质源性神......
目的:研究孔圣枕中丹对血管性痴呆大鼠模型海马神经元细胞的保护作用。方法:40只Wistar大鼠随机分为假手术组、模型组、脑复康组、孔......
目的:观察胶质细胞源性神经营养因子(GDNF)对坐骨神经慢性缩窄性损伤(GCI)小鼠的镇痛作用,探讨其作用的跨膜信息传递机制.方法:1.雄......
Glial cell line-derived neurotrophic factor prevents motoneurons loss in hypoglossal nucleus in skel
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目的:观察养精胶囊是否通过上调POU3F1促进GC-1细胞的增殖,并探讨其具体的信号通路机制.方法:以体外小鼠精原细胞系GC-1细胞培养为模......
Vav2 regulates dopamine transporter-dependent mesolimbic dopamine homeostasis and behavioral respons
Dopamine (DA) homeostasis is essential for a variety of brain activities.Dopamine transporter (DAT)-mediated DA reuptake......
目的 大量证据表明神经营养因子可能参与了精神分裂症的发生,而其中脑源性神经营养因子(BDNF)和胶质源性神经营养因子(GDNF)越来越......
目的:观察人早胚间充质干细胞(hEMSC)对MRL/lpr小鼠的治疗作用及hEMSC治疗对MRL/lpr小鼠Th17、GDNF、PSP的影响.方法:经测定出现大量......
Dopamine(DA)homeostasis is essential for a variety of brain activities.Dopamine transporter(DAT)-mediated DA reuptake is......
Influence of physical exercise on age-related neurodegeneration: studies with models of dopamine def
The motor deficits associated with Parkinson s disease (PD) appear due in large part to the loss of dopamine (DA)-contai......
会议
Changes in gdnf mRNA expression via promoter-specific transcriptional interference in U251 glioma ce
Promoter-targeted siRNA-induced transcriptional gene silencing was recently achieved in mammalian cells.Here,we show tha......
目的:探讨中药复方脑络欣通及其拆方改善气虚血瘀证脑缺血再灌注损伤的作用机制。结论:脑络欣通可通过抑制GFAP的表达,促进bFGF和GDNF......
目的探讨先天性巨结肠患儿不同肠管中SOX-2、SOX-10、GDNF的表达及意义。方法选取2014年1月—2019年8月邢台市人民医院手术治疗的......
Aberrantly expressed GFRα-1/RET in patients with lacrimal adenoid cystic carcinoma is associated wit
Objective: Because of the poor prognosis of lacrimal adenoid cystic carcinoma (LACC), we aimed to investigate the effect......
目的:研究GDNF和雌二醇(E2)联合使用对6-羟基多巴胺(6-OHDA)所致的多巴胺能神经细胞损伤的影响并探讨其作用的机制。方法:新生2~3 ......
Glial cell derived neurotrophic factor (GDNF) holds promises for treating neurodegenerative diseases such as Parkinson’......
目的:探讨移植人脐带间充质干细胞(h UC-MSCs)对脑白质损伤新生大鼠脑内胶质细胞源性神经营养因子(GDNF)含量的影响。方法:取3日龄......
背景:人胶质细胞源性神经营养因子(glialcell line-derived neurotrophic factor,GDNF)和血管内皮生长因子165(vascular endotheli......
Effects of naringin, a lfavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal do
Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruit......
目的:通过拮抗剂阻断A1、P2Y1受体,测定神经胶质细胞源性神经营养因子(GDNF),研究益肾解毒通络法对EAE小鼠神经保护作用的机制,测......
目的:在胰腺导管腺癌(Pancreatic Ductal Adenocarcinoma,PDAC)中筛选神经侵袭(perineural invasion,PNI)相关差异性表达蛋白;利用......
目的:探究胶质细胞源性神经营养因子(GDNF)对水杨酸钠致耳鸣大鼠听皮层及下丘的影响及保护作用,并探讨其可能的作用机制。方法:将2......
目的:观察应用胶质细胞源性神经生长因子( GDNF)在不同时间修复大鼠周围神经损伤的结果。方法:在损伤大鼠周围神经后不同时间段予以修......
目的:克隆可表达人胶质细胞源性神经营养因子的基因.方法:从脑胶质细胞瘤患者术后的脑瘤组织中提取总RNA,以RT-PCR方法扩增出了一......
Neuroprotective effects of BDNF and GDNF in intravitreally transplanted mesenchymal stem cells after
● AIM: To assess the neuro-protective effect of bone marrow mesenchymal stem cells(BMSCs) on retinal ganglion cells(RGC......
体内和体外实验均证明胶质细胞源性的神经营养因子(glial cell line-derived neurotrophicfactor,GDNF)对多巴胺(DA)能神经元有较......
胶质细胞衍生的神经营养因子(GDNF)是多巴胺神经元及运动神经元的营养因子,对由于损伤引起的多巴胺神经元及运动神经元的变性有保......
帕金森氏病(Parkinson’s disease,PD)的概念是1817年英国医生James Parkinson提出的.它是发生于中老年期的一种常见的缓慢进展的......
目的:建立一种可同时分泌多巴胺(DA)和GDNF的工程细胞,并研究其在帕金森病(PD)基因治疗中的可能作用。方法:克隆携带Kozak序列的GDNFcDNA,......
Upregulation of glial cell line-derived neuro- trophic factor mRNA levels in ischemic cerebral corte
Glial cell line-derived neurotrophic factor (GDNF), a distant member of the transforming growth factor-βsuperfamily, h......
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用RTPCR方法扩增并经克隆得胶质细胞源神经营养因子(glialcellinederivedneurotrophicfactor,GDNF)全长基因。实验表明,此基因的表达产物对培养的多巴胺神经元有营养和保护作用。将......
目的:观察携带胶质细胞源性神经营养因子(glialcellinederivedneurotrophicfactor,GDNF)基因的重组腺病毒(AdCMVgdnf)对损伤运动神经元的保护作用。方法:采用培养运动神经元的谷氨酸损伤模型......
近年有关α—synuclein基因、SOD_2基因、ACT基因、胰岛素受体基因、mitNADH脱氢酶基因、MJDI基因、GDNF基因等帕金森病易患基因的......